Protein Details: Aquaporin Z
Protein ID
ICDB_Pro_1153
Protein Name
Aquaporin Z
Gene Name
aqpZ; gll0367
Organism
Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)
Length
248 amino acids
AlphaFoldDB
AF-Q7NNP3-F1-model_v4.pdb
Function
Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
Sequence
MSLVKRSVAEFIGTFWLVLGGCGAAVLAAAFPNLGIGFAGVSLAFGLTLLTMAFAIGHISGCHINPAVSIGLWAAKRFPATELLPYIAAQVLGGIAGAGVLYLIAGGKAGFSLSGGFASNGYGLHSPGGYTLLACLVCEVVMTFMFLMIILGSTDRRAPKGFAPIAIGLSLTLIHLISIPVTNTSVNPARSTGPALFVGDWAIAELWLFWLAPIVGAALAGLFYHAFLDEPGEETEGTPASAQLRTEA
PDB Structures
Ligand Binding
Binding Site
SITE 22: "Involved in tetramerization or stability of the tetramer"; SITE 45: "Selectivity filter"; SITE 175: "Selectivity filter"; SITE 184: "Selectivity filter"; SITE 190: "Selectivity filter"
Disease
Location
DOI ID
10.1093/dnares/10.4.137
RefSeq
NP_923313.1; WP_011140371.1